Abstract: This papers presents the results of experimental testing and single degree of freedom analysis of reinforced concrete columns exposed to simulated blast loads. A total of 13 half-scale reinforced concrete columns were constructed and tested under blast pressures. The columns were designed according to CSA A23.3 (Canadian) standard as first-story columns for both seismic and non-seismic regions. Axial load was applied at levels similar to what can be expected in actual structures. The columns were exposed to different pressure-impulse combinations which resulted in a range of column response. An overview of experimental results is presented which focuses on the measured maximum displacement and time to maximum displacement. The maximum displacements for seismically designed and detailed columns are compared to columns designed and detailed for non-seismic loads. In addition, numerical models were developed, using single degree of freedom dynamic analysis accounting for non-linear material behavior and strain rate effects on material properties, and compared to the experimental results. The results presented in the study provide verification of analytical techniques against experimental data, while also provided valuable design information for performance of reinforced concrete columns exposed to blast loads.